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1

Interrelation of permeation and penetration parameters obtained from in vitro experiments with human skin and skin equivalents

Heike Wagner, Karl-Heinz Kostka, Claus-Michael Lehr, Ulrich F Schaefer

Journal:

Journal of Controlled Release

Year:

2001

Language:

english

File:

PDF, 1.23 MB

english, 2001

2

Zur Selektivität photochemischer Umwandlungen in polychromophoren Molekülen Eine [π2s + π2a + π2a + σ2s]-Reaktion? – Eine ungewöhnliche [π2 + π2]-Cycloaddition

Karl-Heinz Lehr, Rainer Hildebrand, Hans Fritz, Lothar Knothe, Carl Krüger, Horst Prinzbach

Journal:

European Journal of Inorganic Chemistry

Year:

1982

File:

PDF, 1.48 MB

1982

3

Thermolyse des anti-9,9′-Bi[(1α,2β,5β,6α)-tricyclo[4.2.1.02,5]nona-3, 7-dienyliden]-3,3′,4,4′-tetracarbonsäure-tetramethylesters Eine effiziente intramolekulare 1,4-Cyclohexandiyl-Abfangreaktion – Eine vielstufige Isomerisierungssequenz

Karl-Heinz Lehr, Dieter Hunkler, Erich Hädicke, Horst Prinzbach

Journal:

European Journal of Inorganic Chemistry

Year:

1982

File:

PDF, 937 KB

1982

4

Zur Chemie des Biquadricyclanylidens Inter- und Intramolekulare [π2+σ2+σ2]-Cycloadditionen

Karl-Heinz Lehr, Jürgen Werp, Horst Bingmann, Carl Krüger, Horst Prinzbach

Journal:

European Journal of Inorganic Chemistry

Year:

1982

File:

PDF, 1.19 MB

1982

5

Expression of multiple epigenetically regulated cancer/germline genes in nonsmall cell lung cancer

Carolin Grunwald, Michael Koslowski, Tülin Arsiray, Karl Dhaene, Marleen Praet, Anja Victor, Alicia Morresi-Hauf, Michael Lindner, Bernward Passlick, Hans-Anton Lehr, Stephan C. Schäfer, Gerhard Seitz

Journal:

International Journal of Cancer

Year:

2006

Language:

english

File:

PDF, 237 KB

english, 2006

6

Correlation between stratum corneum/water-partition coefficient and amounts of flufenamic acid penetrated into the stratum corneum

Heike Wagner, Karl-Heinz Kostka, Claus-Michael Lehr, Ulrich F. Schaefer

Journal:

Journal of Pharmaceutical Sciences

Year:

2002

Language:

english

File:

PDF, 89 KB

english, 2002

7

Quantification of the enantiomers of ofloxacin in biological fluids by high-performance liquid chromatography

Karl-Heinz Lehr, Petra Damm

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1988

Language:

english

File:

PDF, 552 KB

english, 1988

8

Photoisomerisierung im anti-9,9′-bis-(exo-tricyclo[4.2.1.02,5)nona-3,7-dienyliden)-Gerüst ein [π2s+π2a+π2a+σ2s]

Horst Prinzbach, Karl-Heinz Lehr, Horst Babsch, Hans Fritz

Journal:

Tetrahedron Letters

Year:

1977

Language:

german

File:

PDF, 230 KB

german, 1977

9

Quantification of ciclopirox by high-performance liquid chromatography after pre-column derivatization : An example of efficient clean-up using silica-bonded cyano phases

Karl-Heinz Lehr, Petra Damm

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1985

Language:

english

File:

PDF, 332 KB

english, 1985

10

Human Skin Penetration of Flufenamic Acid: In Vivo/In Vitro Correlation (Deeper Skin Layers) for Skin Samples from the Same Subject

Wagner, Heike, Lehr, Claus-Michael, Schaefer, Ulrich F., Kostka, Karl-Heinz

Journal:

The Journal of Investigative Dermatology

Year:

2002

Language:

english

File:

PDF, 191 KB

english, 2002

11

Immunohistochemical demonstration of mitochondria in routinely processed tissue using a monoclonal antibody

Dr Werner Paulus, Angelika Lehr, Juergen Peiffer, Axel Markovic, Karl Hermann Wiedmann

Journal:

The Journal of Pathology

Year:

1990

Language:

english

File:

PDF, 1.13 MB

english, 1990

12

The Role of Corneocytes in Skin Transport Revised—A Combined Computational and Experimental Approach

Steffi Hansen, Arne Naegel, Michael Heisig, Gabriel Wittum, Dirk Neumann, Karl-Heinz Kostka, Peter Meiers, Claus-Michael Lehr, Ulrich F. Schaefer

Journal:

Pharmaceutical Research

Year:

2009

Language:

english

File:

PDF, 570 KB

english, 2009

13

HMR 1098: An Inhibitor of Cardiac ATP-Sensitive Potassium Channels

Heinz Gögelein, Heinrich C. Englert, Astrid Kotzan, Rüdiger Hack, Karl-Heinz Lehr, Werner Seiz, Reinhard H. A. Becker, Eric Sultan, Bernward A. Schölkens, Andreas E. Busch

Journal:

Cardiovascular Therapeutics

Year:

2000

Language:

english

File:

PDF, 258 KB

english, 2000

14

Influence of the application area on finite dose permeation in relation to drug type applied

Tsambika Hahn, Dominik Selzer, Dirk Neumann, Karl-Heinz Kostka, Claus-Michael Lehr, Ulrich F. Schaefer

Journal:

Experimental Dermatology

Year:

2012

Language:

english

File:

PDF, 365 KB

english, 2012

15

Single-dose pharmacokinetics of cefpirome in patients with renal impairment

Lameire, Norbert, Malerczyk, Vitus, Drees, Barry, Lehr, Karl, Rosenkranz, Bernd

Journal:

Clinical Pharmacology & Therapeutics

Year:

1992

Language:

english

File:

PDF, 957 KB

english, 1992

16

Drug Distribution in Human Skin Using Two Different In Vitro Test Systems: Comparison with In Vivo Data

Heike Wagner, Karl-Heinz Kostka, Claus-Michael Lehr, Ulrich F. Schaefer

Journal:

Pharmaceutical Research

Year:

2000

Language:

english

File:

PDF, 1.22 MB

english, 2000

17

Reduction of postischemic leukocyte-endothelium interaction by adenosine via A2receptor

Dirk Nolte, Anna Lorenzen, Hans-Anton Lehr, Franz-Josef Zimmer, Karl-Norbert Klotz, Konrad Messmer

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Year:

1992

Language:

english

File:

PDF, 511 KB

english, 1992

18

Cigarette smoke elicits leukocyte adhesion to endothelium in hamsters: Inhibition by CuZn-SOD

Hans-Anton Lehr, Eberhard Kress, Michael D. Menger, Hans P. Friedl, Christoph Hübner, Karl E. Arfors, Konrad Messmer

Journal:

Free Radical Biology and Medicine

Year:

1993

Language:

english

File:

PDF, 847 KB

english, 1993

19

Impact of vitamin E supplement in standard laboratory animal diet on microvascular manifestation of ischemia/reperfusion injury

Christian Willy, Joachim Thiery, Michael Menger, Konrad Messmer, Karl E. Arfors, Hans-Anton Lehr

Journal:

Free Radical Biology and Medicine

Year:

1995

Language:

english

File:

PDF, 932 KB

english, 1995

20

Soluplus® as an effective absorption enhancer of poorly soluble drugs in vitro and in vivo

Michael Linn, Eva-Maria Collnot, Dejan Djuric, Katja Hempel, Eric Fabian, Karl Kolter, Claus-Michael Lehr

Journal:

European Journal of Pharmaceutical Sciences

Year:

2012

Language:

english

File:

PDF, 348 KB

english, 2012

21

Do vitamin E supplements in diets for laboratory animals jeopardize findings in animal models of disease?

Hans-Anton Lehr, Peter Vajkoczy, Michael D. Menger, Karl E. Arfors

Journal:

Free Radical Biology and Medicine

Year:

1999

Language:

english

File:

PDF, 374 KB

english, 1999

22

Polynitroxylated hemoglobin-based oxygen carrier: inhibition of free radical-induced microcirculatory dysfunction

Rainer K Saetzler, Karl E Arfors, Ron F Tuma, Usha Vasthare, Li Ma, Carleton J.C Hsia, Hans-Anton Lehr

Journal:

Free Radical Biology and Medicine

Year:

1999

Language:

english

File:

PDF, 97 KB

english, 1999

23

Pharmacological and neurochemical properties of 1,4-diazepines with two annelated heterocycles (‘hetrazepines’)

Karl H. Weber, Franz J. Kuhn, Karin Böke-Kuhn, Erich Lehr, Peter B. Danneberg, Daniel Hommer, Steven M. Paul, Phil Skolnick

Journal:

European Journal of Pharmacology

Year:

1985

Language:

english

File:

PDF, 949 KB

english, 1985

24

Contingent evaluations of marine natural resources are not consistent

Knut Lehre Seip, Karl-Gerhard Hem

Journal:

Marine Pollution Bulletin

Year:

1993

Language:

english

File:

PDF, 239 KB

english, 1993

25

TEWL measurements as a routine method for evaluating the integrity of epidermis sheets in static Franz type diffusion cells in vitro. Limitations shown by transport data testing

Frank Netzlaff, Karl-Heinz Kostka, Claus-Michael Lehr, Ulrich F. Schaefer

Journal:

European Journal of Pharmaceutics and Biopharmaceutics

Year:

2006

Language:

english

File:

PDF, 243 KB

english, 2006

26

In-silico model of skin penetration based on experimentally determined input parameters. Part I: Experimental determination of partition and diffusion coefficients

Steffi Hansen, Andreas Henning, Arne Naegel, Michael Heisig, Gabriel Wittum, Dirk Neumann, Karl-Heinz Kostka, Jarmila Zbytovska, Claus-Michael Lehr, Ulrich F. Schaefer

Journal:

European Journal of Pharmaceutics and Biopharmaceutics

Year:

2008

Language:

english

File:

PDF, 362 KB

english, 2008

27

Improved photostability and reduced skin permeation of tretinoin: Development of a semisolid nanomedicine

Aline Ferreira Ourique, Ana Melero, Cristiane de Bona da Silva, Ulrich F. Schaefer, Adriana Raffin Pohlmann, Silvia Stanisçuaski Guterres, Claus-Michael Lehr, Karl-Heinz Kostka, Ruy Carlos Ruver Beck

Journal:

European Journal of Pharmaceutics and Biopharmaceutics

Year:

2011

Language:

english

File:

PDF, 321 KB

english, 2011

28

Endotoxin accelerates atherosclerosis independent of complement activation

Kurt Reifenberg, Hans-Anton Lehr, Jianglin Fan, Tomonari Koike, Elena Wiese, Ines Küpper, Tolga Atilla Sagban, Stephan C. Schaefer, Ulrich Zähringer, Michael Torzewski, Karl J. Lackner, Sucharit Bhakd

Journal:

Thrombosis Research

Year:

2009

Language:

english

File:

PDF, 667 KB

english, 2009

29

pH profiles in human skin: influence of two in vitro test systems for drug delivery testing

Heike Wagner, Karl-Heinz Kostka, Claus-Michael Lehr, Ulrich F. Schaefer

Journal:

European Journal of Pharmaceutics and Biopharmaceutics

Year:

2003

Language:

english

File:

PDF, 341 KB

english, 2003

30

A New Andean Species of the Hypsiboas pulchellus Group: Adults, Calls, and Phylogenetic Relationships

Lehr, Edgar, Faivovich, Julian, Jungfer, Karl-Heinz

Journal:

Year:

2010

Language:

english

File:

PDF, 872 KB

english, 2010

31

Dabigatran Etexilate in Atrial Fibrillation Patients With Severe Renal Impairment: Dose Identification Using Pharmacokinetic Modeling and Simulation

Lehr, Thorsten, Haertter, Sebastian, Liesenfeld, Karl-Heinz, Staab, Alexander, Clemens, Andreas, Reilly, Paul A., Friedman, Jeffrey

Journal:

Journal of Clinical Pharmacology

Year:

2012

Language:

english

File:

PDF, 719 KB

english, 2012

32

Glimepiride Pharmacokinetics in Obese Versus Non-Obese Diabetic Patients

Shukla, Umesh A, Chi, Eric M, Lehr, Karl-Heinz

Journal:

Annals of Pharmacotherapy

Year:

2004

Language:

english

File:

PDF, 54 KB

english, 2004

33

M1938 Critical Comparison of Genomic Instability in Inflammation-Associated Colorectal Cancer of Man and Mice

Gerling, Marco, Habermann, Jens K., Glauben, Rainer, Meyer, Karl F., Bruch, Hans-Peter, Lehr, Hans-Anton, Zeitz, Martin, Siegmund, Britta

Journal:

Gastroenterology

Year:

2010

Language:

english

File:

PDF, 58 KB

english, 2010

34

Tumorigenicity of Five Dihydrodiols of Benz[a]anthracene on Mouse Skin: Exceptional Activity of Benz[a]anthracene 3,4-dihydrodiol

Alexander W. Wood, Wayne Levin, Richard L. Chang, Roland E. Lehr, Maria Schaefer-Ridder, Jean M. Karle, Donald M. Jerina and Allan H. Conney

Journal:

Proceedings of the National Academy of Sciences

Year:

1977

Language:

english

File:

PDF, 960 KB

english, 1977

35

Mutagenicity and Cytotoxicity of benz[a]anthracene Diol Epoxides and Tetrahydro-Epoxides: Exceptional Activity of the Bay Region 1,2-epoxides

Alexander W. Wood, Richard L. Chang, Wayne Levin, Roland E. Lehr, Maria Schaefer-Ridder, Jean M. Karle, Donald M. Jerina and Allan H. Conney

Journal:

Proceedings of the National Academy of Sciences

Year:

1977

Language:

english

File:

PDF, 1.12 MB

english, 1977

36

A strategy for in-silico prediction of skin absorption in man

Selzer, Dominik, Neumann, Dirk, Neumann, Heike, Kostka, Karl-Heinz, Lehr, Claus-Michael, Schaefer, Ulrich F.

Journal:

European Journal of Pharmaceutics and Biopharmaceutics

Year:

2015

Language:

english

File:

PDF, 612 KB

english, 2015

37

A NEW ANDEAN SPECIES OF THE HYPSIBOAS PULCHELLUS GROUP: ADULTS, CALLS, AND PHYLOGENETIC RELATIONSHIPS

Edgar Lehr, Julian Faivovich and Karl-Heinz Jungfer

Journal:

Year:

2010

Language:

english

File:

PDF, 1.73 MB

english, 2010

38

Significant Pharmacokinetic and Pharmacodynamic Interaction of Warfarin With the NO-Independent sGC Activator HMR1766

Oberwittler, Heike, Hirschfeld-Warneken, Andreas, Wesch, Roland, Willerich, Hans, Teichert, Lenore, Lehr, Karl-Heinz, Ding, Reinhard, Haefeli, Walter Emil, Mikus, Gerd

Journal:

Journal of Clinical Pharmacology

Year:

2007

Language:

english

File:

PDF, 153 KB

english, 2007

39

Tumorigenicity of five dihydrodiols of benz(a)anthracene on mouse skin: exceptional activity of benz(a)anthracene 3,4-dihydrodiol.

Wood, A. W., Levin, W., Chang, R. L., Lehr, R. E., Schaefer-Ridder, M., Karle, J. M., Jerina, D. M., Conney, A. H.

Journal:

Proceedings of the National Academy of Sciences

Year:

1977

Language:

english

File:

PDF, 843 KB

english, 1977

40

Mutagenicity and cytotoxicity of benz[a]anthracene diol epoxides and tetrahydro-epoxides: Exceptional activity of the bay region 1,2-epoxides

Wood, A. W., Chang, R. L., Levin, W., Lehr, R. E., Schaefer-Ridder, M., Karle, J. M., Jerina, D. M., Conney, A. H.

Journal:

Proceedings of the National Academy of Sciences

Year:

1977

Language:

english

File:

PDF, 1.00 MB

english, 1977

41

SIMPLE REDUCTION OF “ZYGOMATIC ARCH” FRACTURES

GRAHAM, WILLIAM P., ACKER, GERALD, ROSENFELD, KARL, LEHR, HERNDON B.

Journal:

The Journal of Trauma Injury Infection and Critical Care

Year:

1970

File:

PDF, 159 KB

1970

42

Vitamin C Prevents Cigarette Smoke-Induced Leukocyte Aggregation and Adhesion to Endothelium in vivo

Hans-Anton Lehr, Balz Frei and Karl-E. Arfors

Journal:

Proceedings of the National Academy of Sciences

Year:

1994

Language:

english

File:

PDF, 1.29 MB

english, 1994

43

Aβ Oligomer Elimination Restores Cognition in Transgenic Alzheimer’s Mice with Full-blown Pathology

Schemmert, Sarah, Schartmann, Elena, Zafiu, Christian, Kass, Bettina, Hartwig, Sonja, Lehr, Stefan, Bannach, Oliver, Langen, Karl-Josef, Shah, Nadim Joni, Kutzsche, Janine, Willuweit, Antje, Willbold,

Journal:

Molecular Neurobiology

Year:

2018

Language:

english

File:

PDF, 1.23 MB

english, 2018

44

Concentrations of Cefpirome in Cerebrospinal Fluid of Children with Bacterial Meningitis after a Single Intravenous Dose

Friedland, Ian R., Sultan, Eric, Lehr, Karl H., Lenfant, Bernard

Journal:

Antimicrobial Agents and Chemotherapy

Year:

1998

Language:

english

File:

PDF, 129 KB

english, 1998

45

Geschichte des Forst- und Jagdwesens in Deutschland

Both, Karl, Lehr, J., Conrad, J., Lavoleye, Emile de

Journal:

Jahrbücher für Nationalökonomie und Statistik

Year:

1880

File:

PDF, 1.07 MB

1880